First Human Clinical Trial Conducted on the ‘Mother of All Cannabinoids’

Another monstrous medicinal constituent based in cannabis plants is gaining popularity and can one day become as popular as CBD (cannabidiol).

The first clinical study exploring the way that CBG influences anxiety and tension in people, all 34 of the volunteers were considered healthy.

CBG has only just been named the ‘mother of all cannabinoids’ because this compound can easily transform into CBD and THC, the psychoactive substance of marijuana.

Consuming a CBG tincture in the recent trial lead to immense reduction in anxiety and stress by the participants after an hour of consumption compared to when they ingested the placebo.

Much to the researchers’ amazement, the participants also demonstrated somewhat improved scores in verbal memory tests after consuming CBG.

Earlier research has demonstrated that substances derived from marijuana having THC have the ability of reducing the measured scores in verbal memory by a similar measure.

However, similar to the previously discussed CBD, CBG does not cause the high associated with THC consumption.

Washington State University’s Psychologist Carrie Cuttler and her team feel that the results are interesting but warn against taking the rapidly expanding CBG market and hyping it without sustained research like how CBD had been done.

‘It would also be interesting to test whether CBG could might reverse the negative impact of THC on verbal memory, as CBD was once said to do, but subsequent attempts to replicate it were always negated,’ the authors concluded in the published document.

CBD is the most famous non-psychotropic Cannabinoid at the moment, with the prospects of curing insomnia, anxiety, and potentially chronic pain. Many of them have such jingle-like slogans and more often than not the scientific proof of such supplements is scanty or non-existent.

This is even more true for CBG, since it does not compete directly with the traditional forms of business investments.

‘We must never find ourselves making improper statements to the effect that CBG is just a miracle drug’ advises Cuttler.

“It is new its exciting, but one has to replicate it and do more research. ”

CBG remains in cannabis plants at very low amounts and was for the longest time forgotten in the presence of THC and CBD.

Of the about 100 cannabimimetic substances identified in the cannabis plant genus, CBG has stood out of the rest due to its encouraging outcomes from the research done on it.

It has been found that CBG has some general anti-inflammatory and analgesic activity, and a decrease in seizures in mouse models of childhood epilepsy.

Up to this date, there are only two published human clinical trials on CBG with neither of them exploring its possibility to relieve anxiety.

The changes targeted by Cuttler and her colleagues’ recent experiments should help in this regard.

Non-suspects in the first part of the trial were divided into two groups; one was given a placebo, and the other took a CBG tincture. The participants and the researchers were blind to which treatment the other participant received.

Following the consumption of the tincture, the participants were asked to rate their mood, stress, anxiety and other parameters like feelings of being high or drunk and side effects like dry throat or eyes, at 20 minutes, 45 minutes and 60 minutes after tincture consumption.

The same test was conducted one week later with the subjects who earlier took the placebo now given the tincture and the others given the placebo.

When the experiments were conducted with the help of the Zoom application, people who took CBG only had a lower result in one type of general anxiety test not in the type of the specific anxiety test.

Nonetheless, these restrictions made sense considering the fact that the preliminary outcomes of CBG’s anxiolytic and anticatastrophic efficacy are consistent with a priori survey results conducted by some of the authors of the work.

In the survey, the participants had admitted to taking CBG for the treatment of anxiety with majority of then noting that the extract was more effective than conventional drugs.

A similar amount also stated that they use CBG for depression; however, the current trial did not reveal any impact on the participants’ mood.

This may be due to the experiment’s low dosage of CBG or the already low depression rates in the small study cohort.

“CBG is becoming increasingly popular, with more producers making bold, unsubstantiated claims about its effects,” says Cuttler.

“Our study is one of the first to provide evidence supporting some of these claims, helping to inform both consumers and the scientific community.

The study was published in Scientific Reports.

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